Carbohydrates are indispensable to life on Earth. In their simplest form, they serve as an elemental energy source for supporting life. For the most part, however, carbohydrates exist not as isolated sugars but as intricate molecular conjugates, or glycans. Glycans come in many forms and sizes, from simple chains (polysaccharides) to strongly branched molecules bristling with antennae-like arms. And although proteins and nucleic acids such as DNA have traditionally attracted far more scientific attention, glycans are also vital to life. They are ubiquitous in nature, forming the intricate sugar coat that surrounds the cells of virtually every organism and filling the spaces between these cells. As part of this so-called extracellular matrix, glycans, with their diverse chemical configurations, have a crucial role in transmitting important biochemical messages from and between cells. In this way, these sugars control the cellular communication that is essential for healthy cell and tissue development and physiological function.
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